Services

End-to-end provider of plasmid DNA production services –

projects tailored to client need.

Custom Plasmid DNA Construction

Construct new plasmid designs or modify existing plasmids using cutting-edge recombinant DNA techniques.

Plasmid DNA Manufacturing

Plasmid production to 50 milligram scale for research and pre-clinical applications using scalable, GMP-compatible, tech-transferable processes.

Rapid Plasmid Prep Services

Rapid plasmid preps at mini, midi, maxi, mega, and giga scale with turnaround times as short as 3 days and prices as low as $100 per sample.

Plasmid QC and Analytics Services

Comprehensive array of analytical testing services for plasmid DNA quality control.

DNA Sequencing Services

We provide NGS services for amplicons, plasmids, and microbial genomes with prices as low as $60 per sample.

Plasmid Construction

Denovo synthesis of complex plasmid designs, including large plasmids, poly-A tails, and ITRs.

Cell Line Generation

Transformation of plasmid production strain and preparation of Research Cell Bank.

Fermentation

Scale up cultivation of producing cell line in animal-free process in flasks or bioreactors.

Downstream Processing

Cell lysis, clarification, chromatographic purification processes, formulation, and vialing.

Analytical Characterization

Complete QC analysis of manufactured material (see available methods below).

Delivery

Plasmid material shipped to client on dry ice along with Certificate of Analysis.

Plasmid Construction

Denovo synthesis of complex plasmid designs, including large plasmids, poly-A tails, and ITRs.

Cell Line Generation

Transformation of plasmid production strain and preparation of Research Cell Bank.

Fermentation

Scale up cultivation of producing cell line in animal-free process in flasks or bioreactors.

Downstream Processing

Cell lysis, clarification, chromatographic purification processes, formulation, and vialing.

Analytical Characterization

Complete QC analysis of manufactured material (see available methods below).

Delivery

Plasmid material shipped to client on dry ice along with Certificate of Analysis.

We offer a variety of production grades to suit your needs.

 

Each project is tailored to help our clients fulfill their research objectives.

 

Contact our team to learn more.

  • Research

  • High-quality

  • GMP

    (Coming Soon)

Research High-quality GMP
PROJECT MANAGEMENT
White-glove service with best-in-class project management capabilities x x x
PLASMID CONSTRUCTION
Scale up of existing plasmid constructs x x x
DNA synthesis & cloning services for new plasmid construction x x x
UPSTREAM PROCESS
Production of research cell bank x x x
Production of master cell bank x
Animal-free media formulations x x x
Shake flask production (multiple scales) x x x
Production in bioreactors (multiple scales) x x
DOWNSTREAM PROCESS
"Established downstream processes producing quality, transfection-grade material" x x x
Endotoxin removal x x x
"Scalable, industry standard downstream process" x x
Animal-free downstream process x x
ANALYTICS
Analytical testing services x x x
Certificate of Analysis x x x
QC Product release testing x x
DOCUMENTATION AND QUALITY ASSURANCE
Master Batch Record x x
Full traceability x
Production in GMP-certified suite x
Physical project segregation in dedicated suite x
Production under QA oversight x

We ensure protection of your data and IP

  • All data is stored in a secured, cloud-based, GxP-rated electronic system.
  • All work is performed in North America.
  • All projects are performed under NDA.

Your plasmid will arrive:

  • Manufactured in accordance with established Standard Operating Procedures.
  • Shipped on dry ice (use of traceable temperature monitoring devices on request).
  • Meeting the quality specifications established at the start of the project.
  • In the agreed-upon quantity.
  • Formulated in your desired buffer and prepared in aliquot sizes of your choice.
  • With a Certificate of Analysis (CoA) listing the results from the QC analysis.


We take pride in the quality of our products.

 

Novel Biotechnology offers a full suite of analytical tests to evaluate various aspects of plasmid quality.

Analytical testing packages can be tailored to each project need.

QC Analysis Methodology
Concentration UV absorption
Purity A260/A280 Ratio
Appearance Visual inspection
Plasmid topology Agarose gel densitometry
Restriction Digest Digestion + agarose gel
Plasmid sequence NGS
Residual host DNA Agarose gel
Residual RNA Agarose gel
Residual protein BCA assay
Endotoxin contamination LAL assay